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Angioimmunoblastic T-cell lymphoma (AITL)

Angioimmunoblastic T-cell lymphoma (AITL)  is a mature T-cell lymphoma of blood or lymph vessel immunoblasts characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement.


Positive  for Pan T cell antigens( CD2, CD3, CD5 and CD7 with frequent aberrant loss of one or more of these antigens),T helper cell marker( CD4), Follicular T helper cell markers (CD10, BCL6, CXCL13 , PD-1 (CD279), ICOS),Follicular dendritic cell networks (CD21, CD23, CD35, CNA.42 or clusterin), Scattered B cells: EBV+ in Lymph nodes

Uncommon expression of CD10 (25%), Lack of CXCL13 expression, PD-1 in 85%, BCL6 / CD3 dual staining in Bone marrow:

Negative for CD8, CD56, pan B cell markers, immunoglobulins, cytotoxic antigens(TCRαβ, TCR γδ), CD1a, CD99, TdT,


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Figure shows The neoplastic cells have the same light scatter distribution as normal T cells in FS/SS PLOT.  Immunophenotyping shows CD7+(dim), CD8-,TCRαβ-, TCR γδ+  CD3 dim, CD16+, CD56-, CD2+, CD20-, CD22-, CD5+, CD38dm, CD10+, CD4+.



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