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B-cell acute lymphocytic leukemia

An aggressive type of leukemia  in which too many B-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood. It is the most common type of acute lymphoblastic leukemia (ALL). Also called B-cell acute lymphocytic leukemia and precursor B-lymphoblastic leukemia.

B-ALL with BCR/ABL1 ,MLL-associated, and other recurrent chromosomal abnormalities. Several cases showed rare aberrancies such as coexistent IGH/BCL2 and MYC rearrangements and raised issues in classification.


B-ALL is subdivided into:

Pro B-ALL: TdT+, CD19+, CD10-

common ALL: CD19+,  CD10+/CALLA+

pre B ALL: CD10+/-, CD19+,  HLA Dr+, cytoplasmic IgM+  

mature B ALL: CD10+, CD19+, CD20+, CD22+, surface IgM+   


B-ALL positive for HLA-DR+, TdT+, CD19+  CD79a+  CD22+, BCR-ABL positive B-ALL is usually CD13 or CD33 positive.

Example :







Above is a case of B-ALL, which shows (Blast-green and lymphocytes-red) positivity of CD19, CD34, CD10, cCD79a, CD58, CD38, CD81 and negative for MPO, cCD3, CD3, CD7, CD13, CD33, CD44, CD117


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  • Pfeifer H, Wassmann B, Pavlova A, et al. Kinase domainmutations of BCR-ABL frequently precede imatinib-basedtherapy and give rise to relapse in patients with de novoPhiladelphia-positive acute lymphoblastic leukemia (Ph+ALL).Blood.2007;110:727-734.

  • Iacobucci I, Ferrari A, Lonetti A, et al. CDKN2A/Balterations impair prognosis in adult BCR-ABL1–positiveacute lymphoblastic leukemia patients.Clin Cancer Res.2011;17:7413-7423.

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