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DR. SANDEEP RAI

(Phd)

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E-mail: sandeeprai82@gmail.com

 

 

PUBLICATIONS:

  • Mohini Mendiratta, Meenakshi Mendiratta, Sujata Mohanty, Sandeep Rai, Ritu Gupta, Vatsla Dadhwal, Sameer Bakhshi, Deepam Pushpam, Mukul Aggarwal, Aditya Kumar Gupta, Ranjit Kumar Sahoo*. Dose Response Immunomodulatory Effects of Culture-Conditioned Media in Acute Graft-versus-Host-Disease. BioRxiv 2025.02.25.640019; doi: https://doi.org/10.1101/2025.02.25.640019 6.

  • Mohini Mendiratta, Meenakshi Mendiratta, Lakshay Malhotra, Sandeep Rai, Vijaya Sarangathem, Prince Dahiya, Ritu Gupta, Sameer Bakhshi, Vatsla Dadhwal, Deepam Pushpam, Mukul Aggarwal, Aditya Kumar Gupta, Prabhat Singh Malik, Raja Pramanik, Manoranjan Mahapatra, Tulika Seth, Sabyasachi Bandyopadhyay, GuruRao Hariprasad, Baibaswata Nayak, Thoudam Debraj Singh, Sachin Kumar, Riyaz Ahmed Mir, Surender Kumar Sharawat, Hridayesh Prakash*, Sujata Mohanty*, Ranjit Kumar Sahoo*. Hypoxia-Mediated Molecular Interactions of Tissue-Specific Mesenchymal Stem Cells Drive Metabolic Reprogramming and Immunomodulation in Acute Graft-versus-Host-Disease. BioRxiv 2025.01.06.630457; doi: https://doi.org/10.1101/2025.01.06.630457

  • Mohini Mendiratta, Praful Pandey, Shobhit Pandey, Sandeep Rai, Ritu Gupta, Sameer Bakhshi, Sabitha Paramasivam, Deepak Garg, Ranjit Kumar Sahoo; Machine Learning Algorithm-Based Prediction of Acute Graft-Versus-Host-Disease at Engraftment through Immune and Cytokine Profile. Blood 2024; 144 (Supplement 1): 7376. doi: https://doi.org/10.1182/blood-2024-212351

  • Mendiratta M, Mendiratta M, Ganguly S, Rai S, Gupta R, Kumar L, Bakhshi S, Dadhwal V, Pushpam D, Malik PS, Pramanik R, Aggarwal M, Gupta AK, Dhawan R, Seth T, Mahapatra M, Nayak B, Singh TD, Kumar S, Mir RA, Kaur G, GuruRao H, Singh M, Prasad CP, Prakash H, Mohanty S, Sahoo RK. Concurrent hypoxia and apoptosis imparts immune programming potential in mesenchymal stem cells: Lesson from acute graft-versus-host-disease model. Stem Cell Res Ther. 2024 Oct 29;15(1):381. doi: 10.1186/s13287-024-03947-2. PMID: 39468660; PMCID: PMC11520827.

  • Mohini Mendiratta, Meenakshi Mendiratta, Sandeep Rai, Ritu Gupta, Sameer Bakhshi, Mukul Aggarwal, Aditya Kumar Gupta, Hridayesh Prakash*, Sujata Mohanty*, Ranjit Kumar Sahoo*. A Comparative Assessment of T-cell response of Healthy Donors and Acute-Graft-versus-Host-Disease Patients: Customizing Immune Monitoring https://doi.org/10.1101/2024.09.05.611044 Platform. BioRxiv 2024.09.05.611044; doi: 8.

  • Mohini Mendiratta, Meenakshi Mendiratta, Shuvadeep Ganguly, Sandeep Rai, Ritu Gupta, Lalit Kumar, Sameer Bakhshi, Vatsla Dadhwal, Deepam Pushpam, Prabhat Singh Malik, Raja Pramanik, Mukul Aggarwal, Aditya Kumar Gupta, Rishi Dhawan, Tulika Seth, Manoranjan Mahapatra, Baibaswata Nayak, Thoudam Debraj Singh, Sachin Kumar Singla, Mayank Singh, Chandra Prakash Prasad, Hridayesh Prakash*, Sujata Mohanty*, Ranjit Kumar Sahoo*. Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease. BioRxiv 2024.04.11.588248; doi: https://doi.org/10.1101/2024.04.11.588248

  • Smeeta Gajendra, MD ∙ Ritu Gupta, MD ∙ Sanjeev Kumar Gupta, MD, DM ∙ Leena Gupta, MD ∙ Sandeep Rai, PhD ∙ Saroj Singh, MSc ∙ Vijay Kumar Prajapati, MSc ∙ Sameer Bakhshi, MD, DM ∙ Rachna Seth, MD. ALL-248 Measurable Residual Disease Assessment by Flow Cytometry in T-Cell Acute Lymphoblastic Leukemia. September 2024. Clinical Lymphoma, Myeloma and Leukemia 24:S159. DOI: 10.1016/S2152-2650(24)00419-1.

  • Das N, Panda D, Gajendra S, Gupta R, Thakral D, Kaur G, Khan A, Singh VK, Vemprala A, Bakhshi S, Seth R, Sahoo RK, Sharma A, Rai S, Prajapati VK, Singh S. Immunophenotypic characterization of leukemic stem cells in acute myeloid leukemia using single tube 10-colour panel by multiparametric flow cytometry: Deciphering the spectrum, complexity and immunophenotypic heterogeneity. Int J Lab Hematol. 2024 Aug;46(4):646-656. doi: 10.1111/ijlh.14250. Epub 2024 Mar 8. PMID: 38456256.

  • Gajendra S, Anupurba S, Gupta R, Mallick S, Panda D, Thakral D, Gupta SK, Bakhshi S, Seth R, Rai S, Prajapati VK, Singh S. Acute myeloid leukemia with RAM immunophenotype: A new underdiagnosed entity. Int J Lab Hematol. 2023 Aug;45(4):541-552. doi: 10.1111/ijlh.14076. Epub 2023 Apr 20. PMID: 37078511.

  • Thakral, D, Singh, V.K, Gupta, R, Jha N, khan A, Kaur G, Rai S, Kumar V, Supriya M, Bakshi S, Seth R. Integrated single-cell transcriptome analysis of CD34 + enriched leukemic stem cells revealed intra- and inter-patient transcriptional heterogeneity in pediatric acute myeloid leukemia. Ann Hematol 102, 73–87 (2023). https://doi.org/10.1007/s00277-022-05021-4

  • Gajendra S, Gupta R, Thakral D, Gupta SK, Jain G, Bakhshi S, Sharma A, RK, Lalit Kumar, Rai S, Singh S, Upadhyay AD. CD34 negative HLA-DR negative Acute Myeloid Leukemia: A higher association with NPM1 and FLT3-ITD mutations" Int J Lab Hematol. 2022; 1- 8. doi:10.1111/ijlh.14007.

  • Rai, S, Das, N, Gupta, R, et al. Utility of CD229 as novel marker in measurable residual disease assessment in multiple myeloma—An evidence-based approach. Int J Lab Hematol. 2022; 1- 8. doi:10.1111/ijlh.13992

  • Das, N., Dahiya, M., Gupta, R., Kumar, L., Sharma, A., Rai, S., Singh, S., Prajapati, V. K., Sahoo, R. K., & Gogia, A. (2022). Relevance of polyclonal plasma cells and post-therapy immunomodulation in measurable residual disease assessment in multiple myeloma. Cytometry Part B: Clinical Cytometry, 102(3), 209– 219. https://doi.org/10.1002/cyto.b.22068

  • Das, N., Dahiya, M., Gupta, R., Rai, S., Singh, S., Prajapati, V. K., Kumar, L., Sharma, A., Sahoo, R. K., & Gogia, A. (2022). Flow cytometric immunophenotyping of plasma cells across the spectrum of plasma cell proliferative disorders: A fresh insight with pattern-based recognition. Cytometry Part B: Clinical Cytometry, 1–11. https://doi.org/10. 1002/cyto.b.22062.

  • Pediatric malignancy or acquired pure red cell aplasia- Diagnostic dilemma in pediatric case. submitted to AJBR

  • Jacob R, Dhanda H, Ali S, Gupta P, Rai S, Rishi B, Misra A. Hypocellular AML versus MDS-diagnostic challenge case report with review of literature. Am J Blood Res. 2022 Oct 15;12(5):172-176. PMID: 36419570; PMCID: PMC9677182.

  • Sen A, Thakkar H, Vincent V, Rai S, Singh A, Mohanty S, Roy A, Ramakrishnan L. Endothelial colony forming cells (ECFCs) tetrahydrobiopterin level in coronary artery disease patients and its association with circulating endothelial progenitor cells. Can J Physiol Pharmacol. 2022 Feb 18. doi: 10.1139/cjpp-2021-0548. Epub ahead of print. PMID: 35180005.

  • Siraj F, Tanwar P, Singh A, Rishi B, Ranjan A, Chopra A, Rai S, Bakhshi S, Misra A. Analysing "tear-drop" prints of acute promyelocytic leukemia (APML): immunophenotypic prognostication of APML by FCM. Am J Blood Res. 2021 Aug 15;11(4):446-457. PMID: 34540354; PMCID: PMC8446832.

  • Das N, Gupta R, Gupta SK, Bakhshi S, Seth R, Kumar C, Rai S, Singh S, Prajapati VK, Gogia A, Sahoo RK, Sharma A, Kumar L. Critical evaluation of the utility of pre- and post-therapy immunophenotypes in assessment of measurable residual disease in B-ALL. Ann Hematol. 2021 Oct;100(10):2487-2500. doi: 10.1007/s00277-021-04580-2. Epub 2021 Jul 8. PMID: 34236495.

  • Chauhan S, Rishi B, Tanwar P, Mehdi G, Arif SH, Rabbani T, Rai S, Siraj F, Misra A. Therapeutic lessons from transfusion in pregnancy-effect on hematological parameters and coagulation profile. Am J Blood Res. 2021 Jun 15;11(3):303-316. PMID: 34322295; PMCID: PMC8303008.

  •  Rai S, Singh S, Gupta R. Prognostic significance of CD56 and CD7 in acute myeloid leukaemia and their outcome. Am J Blood Res. 2020 Aug 25;10(4):109-117. PMID: 32923090; PMCID: PMC7486483.

  • Das N, Gupta R, Gupta SK, Bakhshi S, Malhotra A, Rai S, Singh S, Prajapati VK, Sahoo RK, Gogia A, Sharma A, Kumar L. A Real-world Perspective of CD123 Expression in Acute Leukemia as Promising Biomarker to Predict Treatment Outcome in B-ALL and AML. Clin Lymphoma Myeloma Leuk. 2020 Oct;20(10):e673-e684. doi: 10.1016/j.clml.2020.05.004. Epub 2020 May 11. PMID: 32561191.

  • Rai S, Singh S, Gupta R. Levels of expression of CD45 for normal lymphocytes in different leukemic cases by flowcytometry. Indian J Pathol Microbiol. 2020 Jul-Sep;63(3):505-506. doi: 10.4103/IJPM.IJPM_188_19. PMID: 32769357.

  • Misra A, Chauhan S, Tanwar P, Singh S, Sharma S, Rai S. Real-Time Compensation in Flow Cytometry: A Real Need of Time. Indian J Hematol Blood Transfus. 2018 Jul;34(3):585-588. doi: 10.1007/s12288-018-0914-4. Epub 2018 Jan 10. PMID: 30127585; PMCID: PMC6081326.

  • Rai S, Bhardwaj U, Misra A, Singh S, Gupta R. Comparison between photostability of Alexa Fluor 448 and Alexa Fluor 647 with conventional dyes FITC and APC by flow cytometry. Int J Lab Hematol. 2018 Jun;40(3):e52-e54. doi: 10.1111/ijlh.12809. Epub 2018 Mar 25. PMID: 29575796.

  • Rai S, Bhardwaj U, Singh S, Misra A. Effect of processing time on analysis of rare event in minimal residual disease study. Indian J Pathol Microbiol. 2017 Jul-Sep;60(3):449-451. doi: 10.4103/IJPM.IJPM_353_16. PMID: 28937402.

  • Bhardwaj U, Rai S. Correlation of MRD status and relapse in acute myeloid    leukemia. Bhardwaj et al., Int J Med Lab Res, 2016, 1(1): 2-8.

  • Soni S, Chopra A, Bakhshi S, Vishwanath A, Verma D, Rai S, Kumar R. Prognostic impact of CD56 in pediatric AML. Int J Lab Hematol. 2015 Dec;37(6): e157-9. doi: 10.1111/ijlh.12402. Epub 2015 Jul 6. PMID: 26147745.

  • Chopra A, Bakhshi S, Pramanik SK, Pandey RM, Singh S, Gajendra S, Gogia A, Chandramohan J, Sharma A, Kumar L, Seth R, Rai S, Kumar R. Immunophenotypic analysis of T-acute lymphoblastic leukemia. A CD5-based ETP-ALL perspective of non-ETP T-ALL. Eur J Haematol. 2014 Mar;92(3):211-8. doi: 10.1111/ejh.12238. Epub 2014 Jan 10. PMID: 24329989.

  • Somasundaram V, Soni S, Chopra A, Rai S, Mahapatra M, Kumar R, Pati H. Value of Quantitative assessment of Myeloid Nuclear Differentiation Antigen expression and other flow cytometric parameters in the diagnosis of Myelodysplastic syndrome. Int J Lab Hematol. 2016 Apr;38(2):141-50. doi: 10.1111/ijlh.12458. Epub 2016 Jan 29. PMID: 26822549.

  • Jaiswal AK, Sidhu A Rai S, Determination of Cetrizine from blood using thin layer chromatography, Institution of chemist (India), 2013.

 

Ph.D Thesis:

Significance of CD7 and CD56 in detection of Minimal Residual Disease in Acute Myeloid Leukemia by multiparameter Flow Cytometry. Also correlate expression with the molecular status (FLT3-ITD, NPM1, CBF and AML-ETO), cytogenetic prognosis (favorable, intermediate and unfavorable overall survival and relapse free survival rate and hazard ratio for OS, RFS, LFS in all groups.

 

AWARDS:

 

  • BD biosciences and The Cytometry Society- India Present BD-TCS Award in clinical research category for 2014 to the paper " Immunophenotypic analysis of T-Acute Lymphoblastic Leukemia. A CD5 Based ETP-ALL perspective of Non ETP-ALL".

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  • Best paper award at TCS 2022 for Relevance of polyclonal plasma cells and post-therapy immunomodulation in measurable residual disease assessment in multiple myeloma. Cytometry Part B: Clinical Cytometry.

 

 

WORKSHOP AND CONFERENCES:

  • TCS Annual Meeting 2018 from 29-30 October, 2018. Organized by: Laboratory Oncology Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, AIIMS, New Delhi

  • CME SERIES ON HEMATO-ONCOPATHOLOGY 23rd -24th JULY, 2016. Organized by: Laboratory Oncology Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, AIIMS, New Delhi

  • 7th Annual Meeting of The Cytometry Society and 15th Indo-US Clinical Cytometry Workshop October 25 -27, 2014 at IRCH, AIIMS, New Delhi

  • APHCON-2014, 29-30 March 2014, PGIMER, Dr Ram Manohar Lohia Hospital, New Delhi, India

  • “First  3 day work shop for the technologists for ICICLE trial on the 12-14 January 2015 at TMH, Mumbai.”

  • “Multicolor Immunophenotyping: Standardization & Application” March 2012 at Tata Memorial Hospital ,Mumbai

  • RGCON 2011 workshop ,Feb 2011 organized byRajiv Gandhi Cancer Institute & Research Centre, Delhi.

 

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