Follicular lymphoma

Follicular lymphoma is the second most common B-cell NHL, accounting for approximately 35% of all cases. Follicular lymphoma is composed of both small centrocytes (cleaved follicle center cells) and large centroblasts (noncleaved follicle center cells). Follicular lymphoma is assigned a grade based upon the percentage of centroblasts present. Follicular lymphoma is classified as grade I when there are 5 or fewer centroblasts per high-power field (HPF), grade II when there are 6 to 15 centroblasts per HPF, and grade III when there are more than 15 centroblasts per HPF.

Most cases of follicular lymphoma exhibit a t(14;18) chromosomal translocation, which results in deregulation of expression of the BCL2 proto-oncogene on chromosome 18.

Immunophenotyping:

Positive for CD10, CD19, CD20 (strong), CD79a, BCL2 within follicles, BCL6 , CD30+ cells in 30% , CD10 frequently is weak / negative in interfollicular infiltrates and in grade III follicular lymphomas , CD10 is sensitive and specific for follicular lymphoma among small B cell lymphomas, positivity may vary (CD11c, CD23, CD25, CD43) and Negative for CD5 , cyclin D1

Case-1

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Above case shows positivity for kappa,CD20, CD10, CD19 dim and negativity for CD5, CD23, CD3

 

 

 

 

Reference:

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