Mantle cell lymphoma (MCL)

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma. There may also be involvement of peripheral blood, spleen, liver, gastrointestinal tract (lymphomatoid polyposis), lung, and pleura. MCL consists of a uniform population of small to medium sized lymphoid cells resembling centrocytes with irregular, indented or clefted nuclei. The cells have condensed nuclear chromatin, inconspicuous nucleoli, and a thin rim of cytoplasm. The growth pattern can be nodular, diffuse, mantle zone or follicular. The blastoid variant contains larger cells with dispersed nuclear chromatin, nucleoli, and increased mitotic activity. MCL has poor prognosis. The median survival is 3 to 4 years. Case have t(11;14)(q13;q32) involving the IGH locus on chromosome 14 and CCND1 (cyclin D1) locus on chromosome 11 leading to overexpression of cyclin D1 which promotes cell proliferation.

Immunophenotype:

MCL expresses CD19, CD20, CD43, surface Ig (usually IgM and IgD) with light chain restriction, FMC-7, and bcl-2. Cyclin D1 is strongly positive. It is CD5+ and CD23- which helps to separate it from CLL/SLL. CD5 expression is sometimes weak or absent in MCL. CD10 and bcl-6 are usually negative.

Case-1

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Above case shows (lymp-red, grans-blue, Monocytes- pink) positivity for CD19, CD20, CD5, CD38, CD22,  K restricted and negativity for Lambda, CD20 ,CD10, CD23, CD3

 

Reference:

  • http://wiki.clinicalflow.com/mantle-cell-lymphoma-mcl

  • Swerdlow SH, Campo E, Seto M, Muller-Hermelink HK. Mantle cell lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA,Stein H,

  • et al., editors. WHO Classification of Tumours of Haemopoieticand Lymphoid Tissue. 4thed. Lyon: International Agency for Research onCancer (IARC); 2008. p. 229-32.

  • Lister TA, Crowther D, Sutcliffe SB, Glatstein E, Canellos GP, Young RC,et al.Report of a committee convened to discuss the evaluation and stagingof patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol1989;7:1630-6.

  • Smedby KE, Hjalgrim H. Epidemiology and etiology of mantle celllymphoma and other non-Hodgkin lymphoma subtypes. Semin Cancer Biol2011;21:293-8.

  • A clinical evaluation of the International Lymphoma Study Groupclassification of non-Hodgkin’s lymphoma. The Non-Hodgkin’s lymphomaclassification project. Blood 1997;89:3909-18.

  • Gujral S, Agarwal A, Gota V, Nair R, Gupta S, Pai SK,et al.Aclinicopathologic study of mantle cell lymphoma in a single center study

  • in India. Indian J Pathol Microbiol 2008;51:315-22.

  • Naresh KN, Srinivas V, Soman CS. Distribution of various subtypes ofnon-Hodgkin’s lymphoma in India: A study of 2773 lymphomas usingR.E.A.L. and WHO Classifications. Ann Oncol 2000;11:63-7.

  • Bosch F, López-Guillermo A, Campo E, Ribera JM, Conde E, Piris MA,et al.Mantle cell lymphoma: Presenting features, response to therapy, and prognostic factors. Cancer 1998;82:567-75.

  • Bernard M, Gressin R, Lefrère F, Drénou B, Branger B, Caulet-MaugendreS,et al.Blastic variant of mantle cell lymphoma: A rare but highly aggressive

  • subtype. Leukemia 2001;15:1785-91.

  • Jares P, Colomer D, Campo E. Molecular pathogenesis of mantle cellKwatra,et al.: Mantle Cell Lymphoma and Variants172International Journal of Scientific Study | March 2016 | Vol 3 | Issue 12 lymphoma. J Clin Invest 2012;122:3416-23.

  • Argatoff LH, Connors JM, Klasa RJ, Horsman DE, Gascoyne RD.Mantle cell lymphoma: A clinicopathologic study of 80cases. Blood1997;89:2067-78.

  • Roy A, Kar R, Basu D. Nodal mantle cell lymphoma: A descriptive study from a tertiary care center in South India. Indian J Pathol Microbiol2013;56:94-7.

  • Klapper W. Histopathology of mantle cell lymphoma. Semin Hematol2011;48:148-54.

  • Kimura Y, Sato K, Imamura Y, Arakawa F, Kiyasu J, Takeuchi M,et al.Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67index. Cancer Sci 2011;102:1734-41

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