Peripheral T-cell lymphoma (PTCL)

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Peripheral T-cell lymphoma (PTCL) is defined as a diverse group of aggressive lymphomas that develop from mature-stage white blood cells called T-cells and natural killer (NK) cells.

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Immunophenotyping:

The phenotype is usually CD4+/CD8-, TCRβ+ whereas the expression of CD7 and CD5 may be low. Occasionally, CD30 may be positive.

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Reference

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• Burad DK, Therese MM, Nair S. Peripheral T-cell lymphoma: Frequency and distribution in a tertiary referral center in South India. Indian J Pathol Microbiol 2012;55:429-32.  [PUBMED]   

• Paulli M, Berti E. Cutaneous T-cell lymphomas (including rare subtypes). Current concepts. II. Haematologica 2004;89:1372-88.     

• Bekkenk MW, Vermeer MH, Jansen PM, van Marion AM, Canninga-van Dijk MR, Kluin PM, et al. Peripheral T-cell lymphomas unspecified presenting in the skin: Analysis of prognostic factors in a group of 82 patients. Blood 2003;102:2213-9.     

• Rodriguez-Abreu D, Filho VB, Zucca E. Peripheral T-cell lymphomas, unspecified (or not otherwise specified): A review. Hematol Oncol 2008;26:8-20.     

• Rezania D, Sokol L, Cualing HD. Classification and treatment of rare and aggressive types of peripheral T-cell/natural killer-cell lymphomas of the skin. Cancer Control 2007;14:112-23.     

• Gallamini A, Stelitano C, Calvi R, Bellei M, Mattei D, Vitolo U, et al. Peripheral T-cell lymphoma unspecified (PTCL-U): A new prognostic model from a retrospective multicentric clinical study. Blood 2004;103:2474-9.     

• Isohisa T, Nakai N, Kishimoto M, Katoh N. Skin infiltration of nodal peripheral t-cell lymphoma-not otherwise specified identified by skin biopsy of faint eruptions. Indian J Dermatol 2013;58:247.  

• Coiffier B, Berger F, Byron PA, Magaud JP. T-cell lymphomas: immunological, histological, clinical and therapeutic analysis of 63 cases. J Clin Oncol. 1988; 6: 1584-1589.

• Ascani S, Zinzani PL, Gherlinzoni F, et al. Peripheral T-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed according to the R.E.A.L. classification. Ann Oncol. 1997; 8: 583-592.

• The non-Hodgkin's Lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group Classification of non-Hodgkin's lymphoma. Blood. 1997;89: 3909-3918.

• Cheng AL, Chen YC, Wang CH, et al. Direct comparison of peripheral T-cell lymphoma with diffuse B-cell lymphoma of comparable histological grades. Should peripheral T-cell lymphoma be considered separately? J Clin Oncol. 1989;7: 725-731.