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T-cell large granular lymphocyte (LGL)

T-cell large granular lymphocyte (LGL) leukemia is caused by a clonal proliferation of cytotoxic (CD8+) T cells and is characterized clinically by neutropenia, anemia and/or thrombocytopenia, and a modest lymphocytosis.LGL with abundant cytoplasm and fine or coarse azurophilic granules. It can occur in association with multiple autoimmune conditions.T-LGL involves the PB, BM, liver, spleen.


CD3+, TCRαβ+, CD4-, CD8+ (Common type)

1.CD3+, TCR+, CD4+, CD8-(Rare type)

2.CD3+, TCR+, CD4+ and CD8+(Rare type)

3. CD3+, TCRgd+ (CD4 and CD8 expression not well defined)(Rare type)

CD11b, CD56 and CD57 are variably expressed. TIA-1 is usually positive.


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