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Waldenström's macroglobulinemia is a chronic lymphoproliferative disorder characterized by a clonal proliferation of B lymphocytes or lymphoplasmacytic cells in bone marrow or in lymph nodes, or both, and a high concentration of monoclonal IgM M‐protein, typically exceeding 3 g/dL.



Positive for pan-B markers (CD19, CD20, CD22, CD24) together with cytoplasmic immunoglobulin (IgM, IgD), FMC-7, CD25, predominantly kappa (5:1, kappa:lambda ratio),variable CD20, CD22, CD38, variable CD43, CD138  and Negative for CD5 (usually), CD10, CD11c, CD23, BCL2, CD103


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